When the host of a popular conservative radio talk show dies, the Triple Threat Club must narrow down the lengthy list of people who wished him dead.

"Hand of Fate" begins with a suspected terrorist attack, when outspoken radio talk show host Jim Fate is killed by poisonous gas while his show, "The Hand of Fate" is on the air. In the ensuing panic, downtown Portland is evacuated and FBI Special Agent Nicole Hedges is trapped in a high-rise building. Crime reporter Cassidy Shaw is the only journalist brave enough to report from the scene as chaos overtakes the streets. And federal prosecutor Allison Pierce ends up rescuing a toddler separated from her family and taking her to one of the city's overwhelmed hospitals. In the days following Fate's murder, the three colleagues and friends team up to uncover the secrets behind it - and reveal a few secrets of their own.